林海元

胆管癌（CCA）是肝胆系统的一种高致死性腺癌，可分为肝内、肝门周围和远端。每种解剖亚型都有不同的遗传畸变、临床表现和治疗方法。组织学上，传统的肝门周围/远端胆管癌是产生粘蛋白的腺癌或乳头状肿瘤；肝内胆管癌更具异质性，可以根据显示的胆管的水平或大小进行细分。胆管癌通过多步癌发生发展，并先出现发育异常和原位病变。本文讨论了胆管癌及其分子改变。

胆管癌；解剖；分子改变

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