刘志龙,付贤宁,毛鹏博

目的：探讨淋巴细胞/单核细胞比值（LMR）与高胆固醇血症患者血脂水平的相关性。方法：回顾性分析本院2023年1月至2023年6月接诊的高胆固醇血症患者，将符合诊断标准的40例高胆固醇血症患者作为观察组，选取40例同期体检健康人群作为对照组。检测外周血淋巴细胞数量、单核细胞数量并计算其比值。检测两组生化血脂水平并进行比较，包括总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB），分析LMR与血脂水平的相关性并绘制ROC曲线评估其对高胆固醇血症的诊断效能。结果：观察组TC、LDL-C、ApoB水平均显著高于对照组（P＜0.05）；而LMR、HDL-C、ApoA1水平则显著低于对照组（P＜0.05）。LMR与TC、LDL-C、ApoB水平负相关（P＜0.05）；与HDL-C、ApoA1水平呈正相关（P＜0.05）。ROC曲线结果表明LMR预测高胆固醇血症的曲线下面积（AUC）为0.770，当截断值（Cut-off）为2.795时，灵敏度为77.5%，特异性为70%。结论：高胆固醇血症患者LMR与血脂水平具有较强的相关性；LMR在预测高胆固醇血症中具有良好的诊断效能。

高胆固醇血症；淋巴细胞/单核细胞比值；甘油三酯；胆固醇；相关性

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