王娜娜,巴应贵

糖尿病肾病（Diabetic kidney disease，DKD） 是糖尿病患者的一种慢性长期疾病，会改变小血管的结构和功能。肾小管变性和间质基质沉积、细胞焦亡在糖尿病及其常见并发症糖尿病肾病的发生和发展中起着关键作用。肾纤维化是一种肾脏疾病，其特征是结构和功能单位的丧失，成纤维细胞和肌成纤维细胞的增殖以及细胞外基质的积累，导致肾小管间质纤维化。尽管有大量关于细胞焦亡的新发现信息，但细胞焦亡在肾纤维化中的调节作用仍然需要充分理解，并且如何改善临床结果仍然不清楚。因此，本综述系统总结了有关细胞焦亡在糖尿病肾病肾纤维化发病机制中作用的新发现，并讨论了治疗糖尿病肾病及抗纤维化治疗策略的潜在药物。

糖尿病肾病；细胞焦亡；肾间质纤维化

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