Yunusa Saatter,Ahmed Faruk Umar,Mahmud Yerima Iliyasu

目的：【摘 要】： 【摘 要】：榕树因其财产而闻名于世，志贺氏菌作为一种细菌也因其对传统药物的耐药性而闻名。因此，从无花果中合 成了银纳米颗粒。本研究旨在研究从无花果茎树皮水提取物合成的银纳米颗粒对多药耐药（MDR）志贺氏菌的抗志贺氏病 潜力，该志贺氏杆菌是从尼日利亚达马图鲁尤贝州专科医院的患者的临床标本中分离出来的。共对400份腹泻粪便进行了 筛选，以分离志贺氏菌，并使用标准方法确定其抗生素敏感性模式。采用绿色合成方法，利用无花果提取物的植物化学成 分合成银纳米颗粒。使用紫外可见光谱、FTIR和扫描电子显微镜（SEM）分析纳米颗粒的透射率、官能团、尺寸和形状， 并测试其对耐多药志贺氏菌分离株的抗菌活性。志贺氏菌恢复率与患者性别之间无显著差异（P<0.05）。0-10岁年龄组更 易感，40%（36），其次是30岁以上（21）。志贺氏菌还发现对环丙沙星（92%）、克拉维酸阿莫西林（87%）、头孢呋辛 （85%）、链霉素（83.5%）敏感，而最常见的耐药性表现为对纳利西酸（48%）和四环素（27%）。检测到的植物化学物 质包括皂苷、黄酮、生物碱、心苷和单宁。Uv-vis在460nm附近显示宽峰，FTIR显示烷烃羟基的C-H拉伸，SEM显示具有宽 范围形状和尺寸的纳米颗粒。与粗水提取物和AgNO3溶液对MDR志贺菌的活性相比，银纳米颗粒的抗志贺菌活性在10mm 和30mm之间的抑制区更高，表现出增强的活性。在这项研究中，儿童志贺菌病的高流行率表明，该地区的儿童需要改善 卫生状况，需要进行详细检查以治疗成人腹泻。环丙沙星、克拉维酸阿莫西林、纳利西酸只能在培养和敏感性结果占优势 的情况下使用。增强型传统医学因其潜力而应优先考虑。这项研究证明了绿合成梧桐病毒作为一种有效的抗志贺菌病来对 抗该疾病的全球负担的可行性。这是该地区首次对悬铃木茎皮水提取物对抗志贺菌的研究。

纳米颗粒；志贺菌病；腹泻病；达马图鲁；无花果；耐多药

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